01CYTOTOXICITY
ATEC offers quantitative assays to measure toxicity and discriminate mechanisms. These can be applied in conjunction with efficacy assays in a wide variety of models.
In vitro assays include:
- Cell viability (dye exclusion/retention, enzyme release, ATP, REDOX/ metabolic, morphology)
- Cell proliferation (BrdU)
- Apoptosis (caspase, DNA fragmentation)
In vivo models, with appropriate histological and biochemical assays, in a range of animal species include:
- Skin-flap survival
- Implant survival
- Inflammatory response
Accreditation from NATA for GLP level cytotoxicity testing is in progress.
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ATEC Ltd is an Australian tissue engineering company providing expert contract R&D and testing services to commercial and public-sector clients.
Based within the world-renowned Bernard O’Brien Institute for Microsurgery in Melbourne, ATEC offers technical excellence, and access to uniquely productive biological models.
In addition to cytotoxicity, these include quantitative in vitro and in vivo angiogenesis assays; matrix development and formulation testing; and a variety of unique models for target tissue growth (including cardiac, pancreatic islet, adipose, and liver) in proprietary tissue engineering chambers in small and large animals. Stem cell isolation, propagation, and in vitro and in vivo differentiation analyses complement these tissue engineering models. Human organoid models in nude rats and mice are in development, and ATEC is open to proposals for co-development. |
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For further information, or to discuss your specific project needs, please contact:
Australian Tissue Engineering Centre Limited
ABN 42 112 321 30
Level 3
42 Fitzroy Street
Fitzroy Victoria 3065
P: + 613 9288 3499
F: + 613 9288 3535
AUSTRALIAN TISSUE ENGINEERING CENTRE ABN 42 112 321 310